Anti-AMCase/CHIA Antibody Picoband® fluoro647 Vervoeging

The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene.

Insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3; Igfbp3; Igfbp-3

CHIA

27159

Q9BZP6

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human AMCase/CHIA recombinant protein (Position: L228-A476) .

Flow Cytometry

Angiogenesis, Apoptosis, Associated Proteins, Atherosclerosis, Cancer, Cardiovascular, Cell Biology, Cell Death, Diabetes-associated, Growth Factors/Hormones, Metabolism, Obesity, Protein Phosphorylation, Receptors, Signal Transduction, Tyrosine Phosphatases

Immunogen affinity purified.

Liquid

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

1. Boot, R. G., Blommaart, E. F. C., Swart, E., Ghauharali-van der Vlugt, K., Bijl, N., Moe, C., Place, A., Aerts, J. M. F. G. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. J. Biol. Chem. 276: 6770-6778, 2001. 2. Reese, T. A., Liang, H.-E., Tager, A. M., Luster, A. D., Van Rooijen, N., Voehringer, D., Locksley, R. M. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447: 92-96, 2007. 3. Saito, A., Ozaki, K., Fujiwara, T., Nakamura, Y., Tanigami, A. Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member. Gene 239: 325-331, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

52 kDa

6

Insulin-like growth factor binding protein 3

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.