Anti-Angiomotin/AMOT Antibody Picoband® fluoro488 Vervoeging

Angiomotin (AMOT) is a protein that in humans is encoded by the AMOT gene. This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

Endothelial cell-specific molecule 1; ESM-1; ESM1

AMOT

154796

Q4VCS5

Human

No cross-reactivity with other proteins.

E.coli-derived human Angiomotin/AMOT recombinant protein (Position: T12-Q622) .

Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.

Flow Cytometry

Cell Type Markers, Tags & Cell Markers

Immunogen affinity purified.

Liquid

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.

1. Aase, K., Ernkvist, M., Ebarasi, L., Jakobsson, L., Majumdar, A., Yi, C., Birot, O., Ming, Y., Kvanta, A., Edholm, D., Aspenstrom, P., Kissil, J., Claesson-Welsh, L., Shimono, A., Holmgren, L. Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Genes Dev. 21: 2055-2068, 2007. 2. Bratt, A., Wilson, W. J., Troyanovsky, B., Aase, K., Kessler, R., Van Meir, E. G., Holmgren, L. Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. Gene 298: 69-77, 2002. Note: Erratum: Gene 310: 221 only, 2003. 3. Kikuno, R., Nagase, T., Ishikawa, K., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 197-205, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Endothelial cell specific molecule 1

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.