Anti-Antitrombine III/SERPINC1 Antibody Picoband® 0,00647 Vervoeging

Serpin peptidase inhibitor, clade C (antithrombin), member 1, also known as Antithrombin III (AT3) is the most important inhibitor of thrombin OMBIN III and other coagulation proteinases. This gene is mapped to 1q25.1. The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

Tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD253; TNFSF10; APO2L, TRAIL

SERPINC1

462

P01008

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Antithrombin III/SERPINC1 recombinant protein (Position: R89-K464) .

Widespread; most predominant in spleen, lung and prostate.

Flow Cytometry

Apoptosis, Atherosclerosis, Cancer, Cardiovascular, Cell Biology, Cell Death, Invasion/Microenvironment, Receptors

Immunogen affinity purified.

Liquid

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

1. Baud, O., Picard, V., Durand, P., Duchemin, J., Proulle, V., Albenc-Gelas, M., Devictor, D., Dreyfus, M. Intracerebral hemorrhage associated with a novel antithrombin gene mutation in a neonate. J. Pediat. 139: 741-743, 2001. 2. Fischer, A. M., Cornu, P., Sternberg, C., Meriane, F., Dautzenberg, M. D., Chafa, O., Beguin, S., Desnos, M. Antithrombin III Alger: a new homozygous AT III variant. Thromb. Haemost. 55: 218-221, 1986.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

33477 MW

6

TNF superfamily member 10

Membrane ; Single-pass type II membrane protein .

Tumor necrosis factor ligand superfamily member 10

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.