Anti-Apg3 (Atg3) Konijn Monoklonale Antilichaam

Boster Bio Anti-Apg3 (Atg3) Rabbit Monoclonal Antibody catalog # M01768. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Ubiquitin-like-conjugating enzyme ATG3;6.3.2.-; Autophagy-related protein 3; APG3-like; hApg3; Protein PC3-96; ATG3; APG3, APG3L

ATG3

64422

Q9NT62

Human, Mouse, Rat

A synthesized peptide derived from human Apg3 (Atg3)

Clone: ABBC-1

Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta. .

WB, IHC, ICC, IF

DNA/Nucleotides, DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling

Affinity-chromatography

0.5mg/ml

Liquid

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) . The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE) . This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt) . Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M01768

35864 MW

40 kDa

Ubiquitin-like-conjugating enzyme ATG3

Cytoplasm .

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.