Anti-Aquaporine 6/AQP6 Antibody Picoband® fluoro647 Vervoeging

Aquaporin 6, kidney specific is a protein in humans that is encoded by the AQP6 gene. The aquaporins (AQPs) are a family of water-transporting proteins that facilitate osmotically driven water movement across cell plasma membranes. Among the seven human aquaporins cloned to date (AQPs 0-6), genes encoding the four most closely related aquaporins (AQP0, AQP2, AQP5, and AQP6) have been mapped to chromosome band 12q13, suggesting an aquaporin family gene cluster at this locus. Unlike other aquaporins, AQP6 functions not as a water channel but as an anion-selective channel. Single-channel analyses have shown AQP6 to flicker rapidly between closed and open status.

Aquaporin-6; AQP-6; Aquaporin-2-like; Kidney-specific aquaporin; hKID; AQP6; AQP2L

AQP6

363

Q13520

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 6.

Flow Cytometry

Channels, Metabolism, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. .

1. Entrez Gene: Aquaporin 6, kidney specific. Retrieved 2012-04-10 2. Ma, T., Yang, B., Umenishi, F., Verkman, A. S. Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. Genomics 43: 387-389, 1997. 3. Liu, K., Kozono, D., Kato, Y., Agre, P., Hazama, A., Yasui, M. Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution. Proc. Nat. Acad. Sci. 102: 2192-2197, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

29370 MW

No cross reactivity with other proteins.

6

Aquaporin-6

Cytoplasmic vesicle membrane ; Multi-pass membrane protein .

Aquaporin-6

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.