Anti-ARA9/AIP Antibody Picoband® 31.0647 Vervoeging

AIP, also known as, ARA9 or XAP-2, is a protein that in humans is encoded by the AIP gene. This gene is mapped to 11q13.2. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. AIP may play a positive role in aryl hydrocarbon receptor-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. It has been shown that AIP is the cellular negative regulator of the hepatitis B virus (HBV) X protein. AIP mutations may be the cause of a familial form of acromegaly, familial isolated pituitary adenoma (FIPA) .

AH receptor-interacting protein; AIP; Aryl-hydrocarbon receptor-interacting protein; HBV X-associated protein 2; XAP-2; Immunophilin homolog ARA9; AIP; XAP2

AIP

9049

O00170

Human

No cross-reactivity with other proteins

E.coli-derived human ARA9 recombinant protein (Position: D91-H330) . Human ARA9 shares 95% amino acid (aa) sequence identity with both mouse and rat ARA9.

Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

Flow Cytometry

Chaperones, Neuroscience, Protein Trafficking, Sensory System, Signal Transduction, Visual System

Immunogen affinity purified.

Liquid

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

1. Carver LA, Bradfield CA (April 1997) . Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. J. Biol. Chem. 272 (17) : 11452–6. 2. Kuzhandaivelu, N., Cong, Y.-S., Inouye, C., Yang, W.-M., Seto, E. XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation. Nucleic Acids Res. 24: 4741-4750, 1996. 3. Occhi G, Trivellin G, Ceccato F, et al. (2010) . Prevalence of AIP mutations in a large series of sporadic Italian acromegalic patients and evaluation of CDKN1B status in acromegalic patients with multiple endocrine neoplasia.. Eur. J. Endocrinol. 163 (3) : 369–376.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

37636 MW

No cross reactivity with other proteins.

6

AH receptor-interacting protein

Cytoplasm.

Contains 1 PPIase FKBP-type domain.

AH receptor-interacting protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.