Anti-ARHGEF6 Antibody Picoband® 31.0550 Vervoeging

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability.

ARHGEF6; COOL2; KIAA0006; PIXA; Rho guanine nucleotide exchange factor 6; Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6

ARHGEF6

9459

Q15052

Human, Mouse

No cross-reactivity with other proteins

E.coli-derived human ARHGEF6 recombinant protein (Position: E54-R765) . Human ARHGEF6 shares 91.2% and 91.3% amino acid (aa) sequence identity with mouse and rat ARHGEF6, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Gallo, G., Letourneau, P. C. Axon guidance: GTPases help axons reach their targets. Curr. Biol. 8: R80-R82, 1998. 2. Gedeon, A. K., Glass, I. A., Connor, J. M., Mulley, J. C. Genetic localisation of MRX27 to Xq24-26 defines another discrete gene for non-specific X-linked mental retardation. Am. J. Med. Genet. 64: 121-124, 1996. 3. Hamosh, A. Personal Communication. Baltimore, Md. 11/21/2018.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

87 kDa

6

Rac/Cdc42 guanine nucleotide exchange factor 6

Rho guanine nucleotide exchange factor 6

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.