Anti-ASPP2 Konijn Monoklonale Antilichaam

Boster Bio Anti-ASPP2 Rabbit Monoclonal Antibody catalog # M02609. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Apoptosis-stimulating of p53 protein 2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2;53BP2; p53-binding protein 2; p53BP2; TP53BP2; ASPP2, BBP

TP53BP2

7159

Q13625

Human

A synthesized peptide derived from human ASPP2

Clone: AOEA-20

Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines. .

WB, IHC, ICC, IF

Cell Biology, Cell Cycle, Cell Cycle Inhibitors

Affinity-chromatography

0.5mg/ml

Liquid

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M02609

125616 MW

45 kDa

Apoptosis-stimulating of p53 protein 2

Cytoplasm, perinuclear region. Nucleus. Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.

T-cell surface glycoprotein CD3 zeta chain

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.