Anti-ATE1 Antibody Picoband® fluoro488 Vervoeging

This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants.

BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5; BAG5; KIAA0873

ATE1

11101

O95260

Human

No cross-reactivity with other proteins.

E.coli-derived human ATE1 recombinant protein (Position: R56-A459) .

Expressed in all tissues examined with lower levels in brain and testis.

Flow Cytometry

Interleukins

Immunogen affinity purified.

Liquid

Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity) . May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. .

1. Hu, R.-G., Sheng, J., Qi, X., Xu, Z., Takahashi, T. T., Varshavsky, A. The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators. Nature 437: 981-986, 2005. 2. Kaji, H., Novelli, G. D., Kaji, A. A soluble amino acid-incorporating system from rat liver. Biochim. Biophys. Acta 76: 474-477, 1963. 3. Karakozova, M., Kozak, M., Wong, C. C. L., Bailey, A. O., Yates, J. R, III, Mogilner, A., Zebroski, H., Kashina, A. Arginylation of beta-actin regulates actin cytoskeleton and cell motility. Science 313: 192-196, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

51200 MW

6

BAG family molecular chaperone regulator 5

Perinuclear region.

BAG family molecular chaperone regulator 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.