Anti-ATG12 Antibody Picoband® fluoro488 Vervoeging

Autophagy related 12 is a protein that in humans is encoded by the ATG12 gene. Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy.

Fibrinogen alpha chain; FGA

ATG12

9140

O94817

Human

No cross-reactivity with other proteins.

E.coli-derived human ATG12 recombinant protein (Position: M68-Q99) .

Detected in blood plasma (at protein level) .

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

1. Mizushima, N., Sugita, H., Yoshimori, T., Ohsumi, Y. A new protein conjugation system in human: the counterpart of the yeast Apg12p conjugation system essential for autophagy. J. Biol. Chem. 273: 33889-33892, 1998. 2. Tanida, I., Tanida-Miyake, E., Komatsu, M., Ueno, T., Kominami, E. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. J. Biol. Chem. 277: 13739-13744, 2002. 3. Ueno, K., Kumagai, T., Kijima, T., Kishimoto, T., Hosoe, S. Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer. Hum. Genet. 102: 63-68, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

94973 MW

6

Fibrinogen alpha chain

Secreted.

Fibrinogen alpha chain

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.