Anti-ATG4C Antibody Picoband® 310647 Vervoeging

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized.

Cationic amino acid transporter 3; CAT-3; CAT3; Cationic amino acid transporter y+; Solute carrier family 7 member 3; SLC7A3; ATRC3, CAT3

ATG4C

84938

Q96DT6

Human

No cross-reactivity with other proteins.

E.coli-derived human ATG4C recombinant protein (Position: M1-L457) .

Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala. .

Flow Cytometry

Amino Acid Metabolism, Amino Acids, Cancer, Channels, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. .

1. Agrotis, A., Pengo, N., Burden, J. J., Ketteler, R. Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells. Autophagy 15: 976-997, 2019. 2. Gross, M. B. Personal Communication. Baltimore, Md. 12/16/2020. 3. Li, M., Hou, Y., Wang, J., Chen, X., Shao, Z.-M., Yin, X.-M. Kinetics comparisons of mammalian Atg4 homologues indicates selective preferences toward diverse Atg8 substrates. J. Biol. Chem. 286: 7327-7338, 2011.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

67169 MW

6

Cationic amino acid transporter 3

Cell membrane; Multi-pass membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.