Anti-ATM (C-terminaal gebied) Antilichaam

Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer predisposition. Activation of ATM after DNA damage involves Cdk5 mediated phosphorylation of Ser-794 followed by autophosphorylation at Ser-1891. Active ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis and DNA repair. The Cdk5–ATM pathway regulates phosphorylation and function of the ATM targets p53 and H2AX in postmitotic neurons. Other known substrates of ATM include Chk2, Chk1, CtIP, 4E-BP1, BRCA1, RPA3, SMC1, FANCD2, Rad17, Artemis, Nbs1, and the I-2 regulatory subunit of PP1. Thus, activation of Cdk5 by DNA damage may be an important initiator of ATM-dependent regulation of cell cycle checkpoints.

Our ATM (C-terminal region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human ATM (C-terminal region) and is protein a purified. It is great for use in ELISA, WB, IP, ICC, FC.

Our ATM (C-terminal region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human ATM (C-terminal region) and is Protein A purified. It is great for use in WB, IP, ICC, FC.

Ataxia telangiectasia mutated, AT1 ATDC TEL1 TELO1

ATM

Q13315

Human

Clone M361 was generated from a recombinant sequence corresponding to amino acids in the C-terminal region of human ATM.

ATM (C-terminal region)

M361

Unconjugated

ELISA, WB, IP, ICC, FC

Epigenetics, Extracellular Matrix Proteins

Protein A Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

370

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Protein A purified culture supernatant.

1:1000

1:100

This antibody detects a 370 kDa* protein corresponding to the molecular mass of ATM on SDS-PAGE immunoblots of human A431 and Jurkat cells.

1:100

Western blots performed on each lot.

Mouse

Liquid

IgG2b

Human

Quality Control: WB

AB_1944426