Anti-ATP1A3 Antibody Picoband® fluoro594 Vervoeging

Sodium/potassium-transporting ATPase subunit alpha-3 is an enzyme that in humans is encoded by the ATP1A3 gene. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

ATP1A3

478

P13637

Human, Mouse, Rat

E.coli-derived human ATP1A3 recombinant protein (Position: D24-D583) . Human ATP1A3 shares 99.8% amino acid (aa) sequence identity with both mouse and rat ATP1A3.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Allocco, A. A., Jin, S. C., Duy, P. Q., Furey, C. G., Zeng, X., Dong, W., Nelson-Williams, C., Karimy, J. K., DeSpenza, T., Hao, L. T., Reeves, B., Haider, S., Gunel, M., Lifton, R. P., Kahle, K. T. Recessive inheritance of congenital hydrocephalus with other structural brain abnormalities caused by compound heterozygous mutations in ATP1A3. Front. Cellular Neurosci. 13: 425, 2019. 2. Anselm, I. A., Sweadner, K. J., Gollamudi, S., Ozelius, L. J., Darras, B. T. Rapid-onset dystonia-parkinsonism in a child with a novel ATP1A3 gene mutation. Neurology 73: 400-401, 2009. 3. Ashmore, L. J., Hrizo, S. L., Paul, S. M., Van Voorhies, W. A., Beitel, G. J., Palladino, M. J. Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity. Hum. Genet. 126: 431-447, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.