Anti-BAFF Receptor/TNFRSF13C Antibody Picoband® fluoro550 Vervoeging

Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), also known as BAFFR, is a protein in humans is encoded by the TNFRSF13C gene. The BAFFR gene is mapped to chromosome 22q13.1-q13.31. It has got 184 amino acid transmembrane protein which is 56% identical to the mouse protein. B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. BAFF plays a crucial role in B cell development and can function through receptors other than BCMA.

Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD268; TNFRSF13C; BAFFR, BR3

TNFRSF13C

115650

Q96RJ3

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human BAFF Receptor.

Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.

Flow Cytometry

Growth Factors/Hormones, Signal Transduction

Immunogen affinity purified.

Liquid

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. .

1. Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C (Sep 2001) . BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293 (5537) : 2108–11. doi:10.1126/science.1061965. PMID 11509692. 2. Entrez Gene: TNFRSF13C tumor necrosis factor receptor superfamily, member 13C. 3. Schiemann, B., Gommerman, J. L., Vora, K., Cachero, T. G., Shulga-Morskaya, S., Dobles, M., Frew, E., Scott, M. L.An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.Science293: 2111-2114, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

18864 MW

No cross reactivity with other proteins.

6

Tumor necrosis factor receptor superfamily member 13C

Membrane ; Single-pass type III membrane protein .

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Tumor necrosis factor receptor superfamily member 13C

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.