Anti-BAG2 Antibody Picoband® fluoro594 Vervoeging

BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.

BAG family molecular chaperone regulator 2; BAG-2; Bcl-2-associated athanogene 2; BAG2

BAG2

9532

O95816

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human BAG2, different from the related mouse and rat sequences by two amino acids.

Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus. .

Flow Cytometry

Apoptosis, Apoptotic Markers, Cancer, Cell Biology, Cell Death, Chaperones, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes, Protein Trafficking, Signal Transduction

Immunogen affinity purified.

Liquid

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

1. Takayama S, Xie Z, Reed JC (Feb 1999) . An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem 274 (2) : 781–6. Entrez Gene: BAG2 BCL2-associated athanogene 2

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

23772 MW

No cross reactivity with other proteins.

6

BAG family molecular chaperone regulator 2

Cytoplasm .

BAG family molecular chaperone regulator 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.