Anti-BAL/SLC27A5 Antibody Picoband® fluoro488 Vervoeging

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene. The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS) . It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.

A-kinase anchor protein 2; AKAP-2; AKAP-KL; Protein kinase A-anchoring protein 2; PRKA2; AKAP2; KIAA0920, PRKA2

SLC27A5

10998

Q9Y2P5

Human, Rat

No cross-reactivity with other proteins.

E.coli-derived human BAL/SLC27A5 recombinant protein (Position: I204-L690) .

Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.

Flow Cytometry

Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Immunogen affinity purified.

Liquid

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity) . .

1. Berger, J., Truppe, C., Neumann, H., Forss-Petter, S. A novel relative of the very-long-chain acyl-CoA synthetase and fatty acid transporter protein genes with a distinct expression pattern. Biochem. Biophys. Res. Commun. 247: 255-260, 1998. 2. Chong, C. P. K., Mills, P. B., McClean, P., Gissen, P., Bruce, C., Stahlschmidt, J., Knisely, A. S., Clayton, P. T. Bile acid-CoA ligase deficiency--a new inborn error of bile acid metabolism. J. Inherit. Metab. Dis. 35: 521-532, 2012. 3. Doege, H., Baillie, R. A., Ortegon, A. M., Tsang, B., Wu, Q., Punreddy, S., Hirsch, D., Watson, N., Gimeno, R. E., Stahl, A. Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic liver homeostasis. Gastroenterology 130: 1245-1258, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

94661 MW

6

A-kinase anchor protein 2

Secreted .

A-kinase anchor protein 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.