Anti-Band 4.1-achtig eiwit 1 EPB41L1 Antibody Picoband® fluoroc647 Vervoeging

Band 4.1-like protein 1 is a protein that in humans is encoded by the EPB41L1 gene. This gene is mapped to 20q11.23. It is found that a heterozygous missense mutation in the EPB41L1 gene causing nonsyndromic intellectual disability. This gene may function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. EPB41L1 has been shown to interact with ITPR1, Dopamine receptor D2, Dopamine receptor D3, CENTG1 and Nuclear mitotic apparatus protein 1.

Band 4.1-like protein 1; Neuronal protein 4.1;4.1N; EPB41L1; KIAA0338

EPB41L1

2036

Q9H4G0

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human EPB41L1, different from the related mouse and rat sequences by one amino acid.

Highest expression in brain, lower in heart, kidney, pancreas, placenta, lung and skeletal muscle.

Flow Cytometry

Actin Binding Proteins, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Plasma Membrane, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Immunogen affinity purified.

Liquid

May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.

1. Binda, Alicia V; Kabbani Nadine, Lin Ridwan, Levenson Robert (September 2002) . D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N. Mol. Pharmacol. (United States) 62 (3) : 507–13. 2. Hamdan, F. F., Gauthier, J., Araki, Y., Lin, D.-T., Yoshizawa, Y., Higashi, K., Park, A.-R., Spiegelman, D., Dobrzeniecka, S., Piton, A., Tomitori, H., Daoud, H., and 22 others. Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Am. J. Hum. Genet. 88: 306-316, 2011. Note: Erratum: Am. J. Hum. Genet. 88: 516 only, 2011. 3. Kim AC, Van Huffel C, Lutchman M, Chishti AH (June 1998) . Radiation hybrid mapping of EPB41L1, a novel protein 4.1 homologue, to human chromosome 20q11.2-q12. Genomics 49 (1) : 165–6.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

99 kDa

No cross reactivity with other proteins.

6

Band 4.1-like protein 1

Cytoplasm, cytoskeleton.

Contains 1 FERM domain.

Band 4.1-like protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.