Anti-BAP1 (BRCA1 geassocieerd eiwit 1) Monoklonale antilichamen (Kloon: BAP1/2431)

The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

BAP1; BRCA1 associated protein 1; Cerebral protein 13; Cerebral protein 6; HUCEP 13; Hucep 6; HUCEP13; Hucep6; TPDS; Ubiquitin carboxy terminal hydrolase; Ubiquitin carboxyl terminal hydrolase BAP1; UCHL2

BAP1

8314

Q92560

Human

Recombinant human BAP1 protein fragment (around aa 191-326) (exact sequence is proprietary)

BAP1/2431

ELISA

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

ELISA (For coating, order Ab without BSA)

Mouse IgG2c, kappa