Anti-BCAR4 Antibody Picoband® 0,00647 Vervoeging

This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified.

BCAR4; hCG_1814062

BCAR4

400500

D3DUG6

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthesized peptide derived from human BCAR4.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Godinho, M. F. E., Sieuwerts, A. M., Look, M. P., Meijer, D., Foekens, J. A., Dorssers, L. C. J., van Agthoven, T. Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer. Brit. J. Cancer 103: 1284-1291, 2010. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 2/17/2011.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

13 kDa

6

Breast cancer anti-estrogen resistance 4

Breast cancer antiestrogen resistance 4 protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.