Anti-BCAT1 Antibody Picoband® 31.0550 Vervoeging

BCAT1, Branched-chain Aminotransferase1, is also know as BCT1. The BCAT1 gene is highly expressed early in embryogenesis, and during organogenesis its expression is localized to the neural tube, the somites, and the mesonephric tubules. The gene is also expressed in several MYC-based tumors. The BCAT1 gene is mapped to chromosome 12. Lack of the enzyme BCT can cause auxotroph, a kind of auxotrophic mutant in Chinese-hamster ovary cells that lacks the ability to grow if alpha-ketoisovaleric acid, alpha-ketoisocaproic acid, and alpha-keto-beta-methylvaleric acid are substituted for valine, leucine, and isoleucine in the culture medium.

Branched-chain-amino-acid aminotransferase, cytosolic; BCAT (c) ;2.6.1.42; Protein ECA39; BCAT1; BCT1, ECA39

BCAT1

586

P54687

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human BCAT1, different from the related mouse sequence by one amino acid, rat sequence by three amino acids.

During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.

Flow Cytometry

Amino Acid Metabolism, Amino Acids, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.

1. Naylor, S. L., Shows, T. B.Branched-chain aminotransferase genes (BCT-1 and BCT-2) assigned to human chromosomes 12 and 19 using alpha-keto acid selection media. (Abstract) Cytogenet. Cell Genet. 25: 191-192, 1979. 2. Jones, C., Moore, E. E.Isolation of mutants lacking branched-chain amino acid transaminase.Somat. Cell Genet. 2: 235-243, 1976.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

42966 MW

No cross reactivity with other proteins.

6

Branched-chain-amino-acid aminotransferase, cytosolic

Cytoplasm.

Belongs to the bZIP family.

Branched-chain-amino-acid aminotransferase, cytosolic (BCAT (c) )

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.