Anti-Bcl-2-gerelateerd eiwit A1 Bcl2A1 Antilichaam Picoband® fluoro550 Vervoeging

Bcl-2-related protein A1 (BCL2A1), is the human homolog of the murine A1, and maps to chromosome 15q24.3. The BCL2A1 gene has also been referred to as BCL2L5, BFL1, and GRS. Bfl-1 protein suppresses apoptosis induced by the p53 tumor suppressor protein in a manner similar to other Bcl-2 family members such as Bcl-2, Bcl-xL and EBV-BHRF1. In addition, the bfl-I gene cooperates efficiently with the Ela oncogene in transformation of primary rodent epithelial cells. The human bfl-1 gene may play an important role in carcinogenesis.

Bcl-2-related protein A1; Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS; BCL2A1; BCL2L5, BFL1, GRS, HBPA1

BCL2A1

597

Q16548

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human Bcl2A1.

Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies.

Flow Cytometry

Apoptosis, Cell Biology, Intracellular

Immunogen affinity purified.

Liquid

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity) . Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity) . .

1. Choi, S. S., Park, S. H., Kim, U.-J., Shin, H.-S. Bfl-1, a Bcl-2-related gene, is the human homolog of the murine A1, and maps to chromosome 15q24.3. Mammalian Genome 8: 781-782, 1997. 2. D'Sa-Eipper, C., Subramanian, T., Chinnadurai, G. Bfl-1, a bcl-2 homologue, suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity. Cancer Res. 56: 3879-3882, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

20132 MW

No cross reactivity with other proteins.

6

Bcl-2-related protein A1

Cytoplasm.

Contains 5 BAG domains.

Bcl-2-related protein A1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.