Anti-Bcl-XS/BCL2L1 Antibody Picoband® fluoro488 Vervoeging

Bcl-xS is the second mRNA species of Bcl-x protein, which encodes a protein that inhibits the ability of bcl-2 to enhance the survival of growth factor-deprived cells. In vivo, bcl-xS mRNA is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. Apoptosis was associated with increased protein expression of Bcl-X/S, an early marker of apoptosis, and release of cytochrome c into the cytosol of infected HB cells.

Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; BCL2L1; BCL2L, BCLX

BCL2L1

598

Q07817

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human Bcl-XS, different from the related rat and mouse sequences by one amino acid.

Bcl-X (S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X (L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Flow Cytometry

Apoptosis, Apoptotic Markers, Cancer, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes

Immunogen affinity purified.

Liquid

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

1. Entrez Gene: BCL2L1 BCL2-like 1. 2. Boise LH, González-García M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB (Aug 1993) . bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74 (4) : 597–608.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

26049 MW

No cross reactivity with other proteins.

6

Bcl-2-like protein 1

Isoform Bcl-X (L) : Mitochondrion inner membrane . Mitochondrion outer membrane . Mitochondrion matrix . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane ; Single-pass membrane protein ; Cytoplasmic side . After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity) . Localizes to the centrosome when phosphorylated at Ser-49. .

Belongs to the Bcl-2 family.

Bcl-2-like protein 1 (Bcl2-L-1)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.