Anti-BCL11B Antibody Picoband®

B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene. This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Boster Bio Anti-BCL11B Antibody Picoband® catalog # A01485-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1

BCL11B

64919

Q9C0K0

Human, Rat

No cross-reactivity with other proteins.

E.coli-derived human BCL11B recombinant protein (Position: Q10-A628) .

Predominantly expressed in the liver (PubMed:11099417, PubMed:11452359) . Low expression levels in the small intestine and colon (PubMed:11099417) . Very low levels in other tissues, including brain, heart and spleen (PubMed:11452359) .

ELISA, Flow Cytometry, IF, IHC, ICC, WB

Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Cholesterol Metabolism, Heart Disease, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

1. Arlotta, P., Molyneaux, B. J., Chen, J., Inoue, J., Kominami, R., Macklis, J. D. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron 45: 207-221, 2005. 2. Avram, D., Fields, A., Top, K. P. O., Nevrivy, D. J., Ishmael, J. E., Leid, M. Isolation of a novel family of C2H2 zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J. Biol. Chem. 275: 10315-10322, 2000. 3. Chen, B., Wang, S. S., Hattox, A. M., Rayburn, H., Nelson, S. B., McConnell, S. K. The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex. Proc. Nat. Acad. Sci. 105: 11382-11387, 2008.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A01485-2

75679 MW

116 kDa

6

Flap structure-specific endonuclease 1

Membrane ; Multi-pass membrane protein .

ATP-binding cassette sub-family G member 8

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.