Anti-BCL6 Antibody Picoband® 31.0550 Vervoeging

Bcl-6 (B-cell lymphoma 6) is a protein that in humans is encoded by the BCL6 gene. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

BCL6

604

P41182

Human

E.coli-derived human BCL6 recombinant protein (Position: R28-K336) . Human BCL6 shares 90.6% amino acid (aa) sequence identity with mouse BCL6.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Akasaka, T., Miura, I., Takahashi, N., Akasaka, H., Yonetani, N., Ohno, H., Fukuhara, S., Okuma, M. A recurring translocation, t (3;6) (q27; p21), in non-Hodgkin's lymphoma results in replacement of the 5-prime regulatory region of BCL6 with a novel H4 histone gene. Cancer Res. 57: 7-12, 1997. 2. Barnett, B. E., Ciocca, M. L., Goenka, R., Barnett, L. G., Wu, J., Laufer, T. M., Burkhardt, J. K., Cancro, M. P., Reiner, S. L. Asymmetric B cell division in the germinal center reaction. Science 335: 342-344, 2012. 3. Baron, B. W., Nucifora, G., McCabe, N., Espinosa, R., III, Le Beau, M. M., McKeithan, T. W. Identification of the gene associated with the recurring chromosomal translocations t (3;14) (q27; q32) and t (3;22) (q27; q11) in B-cell lymphomas. Proc. Nat. Acad. Sci. 90: 5262-5266, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

79 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.