Anti-BDNF Antibody Picoband® fluoro488 Vervoeging

Brain-derived neurotrophic factor, also known as BDNF, is a secreted protein that, in humans, is encoded by the BDNF gene. BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor. It is mapped to 11p14.1. BDNF is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain. It is expressed within peripheral ganglia and is not restricted to neuronal target fields. BDNF has been purified and shown to reduce the amount of naturally occurring neuronal cell death in portions of the peripheral nervous system.

Brain-derived neurotrophic factor; BDNF; Bdnf

BDNF

12064

P21237

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human BDNF recombinant protein (Position: H129-R247) . Human BDNF shares 100% amino acid (aa) sequence identity with both mouse and rat BDNF.

Flow Cytometry

Alzheimer's Disease, Atherosclerosis, Cardiovascular, Diabetes, Diabetes-associated, Growth and Development, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Obesity

Immunogen affinity purified.

Liquid

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.

1. Jones, K. R.; Reichardt, L. F. : Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc. Nat. Acad. Sci. 87: 8060-8064, 1990. 2. Lee, R.; Kermani, P.; Teng, K. K.; Hempstead, B. L. : Regulation of cell survival by secreted proneurotrophins. Science 294: 1945-1948, 2001 . 3. Pruunsild, P.; Kazantseva, A.; Aid, T.; Palm, K.; Timmusk, T. : Dissecting the human BDNF locus: biional transcription, complex splicing, and multiple promoters. Genomics 90: 397-406, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

28 kDa

No cross reactivity with other proteins.

6

Brain-derived neurotrophic factor

Secreted.

Brain-derived neurotrophic factor

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.