Anti-Bestrophin-1/Best1 Antibody Picoband®

Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Boster Bio Anti-Bestrophin-1/Best1 Antibody Picoband® catalog # A01936-4. Tested in WB, ELISA applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

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Best1

24115

O88870

Mouse, Rat

No cross reactivity with other proteins.

E.coli-derived mouse Bestrophin-1/Best1 recombinant protein (Position: V9-E551) . Mouse Best1 shares 64.3% amino acid (aa) sequence identity with human Best1.

Expressed in all tissues.

WB, ELISA

Signal Transduction, Signaling Pathway, Small G Proteins

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Allikmets, R., Seddon, J. M., Bernstein, P. S., Hutchinson, A., Atkinson, A., Sharma, S., Gerrard, B., Li, W., Metzker, M. L., Wadelius, C., Caskey, C. T., Dean, M., Petrukhin, K. Evaluation of the Best disease gene in patients with age-related macular degeneration and other maculopathies. Hum. Genet. 104: 449-453, 1999. 2. Bakall, B., Marknell, T., Ingvast, S., Koisti, M. J., Sandgren, O., Li, W., Bergen, A. A. B., Andreasson, S., Rosenberg, T., Petrukhin, K., Wadelius, C. The mutation spectrum of the bestrophin protein--functional implications. Hum. Genet. 104: 383-389, 1999. 3. Boon, C. J. F., Klevering, B. J., den Hollander, A. I., Zonneveld, M. N., Theelen, T., Cremers, F. P. M., Hoyng, C. B. Clinical and genetic heterogeneity in multifocal vitelliform dystrophy. Arch. Ophthal. 125: 1100-1106, 2007.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A01434-2

52588 MW

56,60 kDa

Serine/threonine-protein kinase AtPK1/AtPK6

Cytoplasm. Nucleus.

Serine/threonine-protein kinase AtPK1/AtPK6

IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.