Anti-beta 1 Spectrin/SPTB Antibody Picoband®

Spectrin beta chain, erythrocyte is a protein that in humans is encoded by the SPTB gene. This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described.

Boster Bio Anti-beta 1 Spectrin/SPTB Antibody Picoband® catalog # A02392. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Caspase-2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1; Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12; CASP2; ICH1; NEDD2

SPTB

6710

P11277

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human beta 1 Spectrin/SPTB recombinant protein (Position: M703-Y2137) .

Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.

WB, Flow Cytometry, ELISA

Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes, Proteolysis/Ubiquitin, Proteolytic Enzymes

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

1. Basseres, D. S., Duarte, A. S. S., Hassoun, H., Costa, F. F., Saad, S. T. O. Beta-spectrin S-ta Barbara: a novel frameshift mutation in hereditary spherocytosis associated with detectable levels of mRNA and a germ cell line mosaicism. Brit. J. Haemat. 115: 347-353, 2001. Note: Erratum: Brit. J. Haemat. 116: 925 only, 2002. 2. Basseres, D. S., Vicentim, D. L., Costa, F. F., Saad, S. T. O., Hassoun, H. Beta-spectrin Promissao: a translation initiation codon mutation of the beta-spectrin gene (ATG-to-GTG) associated with hereditary spherocytosis and spectrin deficiency in a Brazilian family. (Letter) Blood 91: 368-369, 1998. 3. Becker, P. S., Tse, W. T., Lux, S. E., Forget, B. G. Beta-spectrin Kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1. J. Clin. Invest. 92: 612-616, 1993.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A02392

270 kDa

6

Caspase 2, apoptosis-related cysteine peptidase

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.