Anti-Beta-synnucleine Antilichaam

Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects nerurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1) .

Our Anti-Beta-synuclein sheep polyclonal primary antibody detects human and rat Beta-synuclein , and is whole serum. It is validated for use in IHC-Frozen.

Our Anti-Beta-synuclein sheep polyclonal primary antibody detects human and rat Beta-synuclein, and is whole serum. It is validated for use in IHC-Frozen.

SNCB

Q16143

Human and Rat

A synthetic peptide (IEPLMEPEGSYEDPPQE) as part of human beta synuclein protein (aa: 108-125) conjugated to diphteria toxid has been used as the immunogen.

Beta-synuclein

Unconjugated

IHC-Frozen

Whole serum

For research use only.

25°C (ambient)

Spin vial briefly before opening. Reconstitute in 100 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

1:3000-1:8000

Known to be specific for beta synuclein. This antiserum is know to react with human, rat and other rodent beta synuclein.

Sheep

Lyophilized

Mixed

Human