Anti-bijlagein A3/ANXA3 Antibody Picoband® fluoro550 Vervoeging

Annexin A3 is a protein that in humans is encoded by the Annexin A3 gene. The Annexin A3 gene contains 13 exons and spans 58 kb of genomic DNA. The Annexin A3 gene is mapped to 4q21. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.

Annexin A3;35-alpha calcimedin; Annexin III; Annexin-3; Lipocortin III; Placental anticoagulant protein III; PAP-III; Anxa3; Anx3

ANXA3

25291

P14669

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of rat Annexin A3, different from the related human and mouse sequences by two amino acids.

Pancreas and other tissues and body fluids (indicating it may have other physiological functions besides its role in digestion) .

Flow Cytometry

Calcium Signaling, Lipid Signaling, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Inhibitor of phospholipase A2, also possesses anti- coagulant properties.

1. Bianchi C, et al. Primary cell cultures from human renal cortex and renal-cell carcinoma evidence a differential expression of two spliced isoforms of Annexin A3. Am J Pathol, 2010 Apr. 2. Jung EJ, et al. Decreased annexin A3 expression correlates with tumor progression in papillary thyroid cancer. Proteomics Clin Appl, 2010 May. 3. Yan X, et al. Increased expression of annexin A3 is a mechanism of platinum resistance in ovarian cancer. Cancer Res, 2010 Feb 15.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

36363 MW

No cross reactivity with other proteins.

6

Annexin A3

Cytoplasm . Nucleus . Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4.

Belongs to the annexin family.

Annexin A3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.