Anti-bot Sialoproteïne/IBSP Antilichaam Picoband® 31.0647 Vervoeging

IBSP (integrin-binding sialoprotein) is also known as BSP. The protein encoded by this gene is a major structural protein of the bone matrix. Bone sialoprotein is an acidic glycoprotein of approximately 70 kD that undergoes extensive posttranslational modifications. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. The BSP gene is mapped to 4q22.1.

Bone sialoprotein 2; Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein; Ibsp

IBSP

15891

Q61711

Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Bone Sialoprotein, different from the related rat sequence by one amino acid.

Flow Cytometry

Structures

Immunogen affinity purified.

Liquid

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity) . .

1. Duncan EL, et al. Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral absorbance and fracture risk. PLoS Genet, 2011 Apr. 2. Gordon JA, et al. Bone sialoprotein stimulates focal adhesion-related signaling pathways: role in migration and survival of breast and prostate cancer cells. J Cell Biochem, 2009 Aug 15.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

35734 MW

No cross reactivity with other proteins.

6

Bone sialoprotein 2

Secreted.

Bone sialoprotein 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.