Anti-Brain-afgeleide neurotrofe factor (BDNF) Antilichaam

BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG) . SIMILARITY: Belongs to the NGF-beta family.

Our Anti-Brain-derived neurotrophic factor (BDNF) mouse monoclonal primary antibody detects human, mouse, other mammals (predicted), and rat Brain-derived neurotrophic factor (BDNF), and is igg. It is validated for use in ELISA, WB.

Our Anti-Brain-derived neurotrophic factor (BDNF) mouse monoclonal primary antibody detects human, mouse, other mammals (predicted), and rat Brain-derived neurotrophic factor (BDNF), and is IgG. It is validated for use in ELISA, WB.

Brain-derived neurotrophic factor; Abrineurin; proBDNF

P23560

Human, Mouse, Other Mammals (Predicted), and Rat

Recombinant human mature BDNF expressed in E.coli

Brain-derived neurotrophic factor (BDNF)

4C8

Unconjugated

ELISA, WB

Technical Note #4 - Acid-Extraction of BDNF From Brain Tissue Instructions for Acid-Extraction of Brain Tissue BDNF Antibodies for Western Blotting

IgG

Lyophilized from a solution containing PBS pH 7.4, 0.1% trehalose, with 0.1% sodium azide.

14 kDa (see application notes)

For research use only.

25°C (ambient)

Spin vial briefly before opening. Reconstitute each vial with 50 μL sterile-filtered, ultrapure water to obtain a concentration of 1 mg/mL. Centrifuge to remove any insoluble material. Store lyophilized antibody at -20°C to -80°C protected from moisture. After reconstitution divide antibody into useful aliquots and keep aliquots at -20°C to -80°C for a higher stability. Working aliquots can be kept at 2-8°C for up to 1 month. Avoid repetitive freeze/thaw cycles.

Protein G purified mouse IgG.

1-4 μg/mL

0.2-2 μg/mL

Detects human, mouse, rat, guinea pig BDNF. Expected to detect BDNF from other species due to sequence homology.

1-4 μg/mL

Mouse

Lyophilized

IgG

Human