Anti-BRD9 Antibody Picoband® 31.0647 Vervoeging

Bromodomain-containing protein 9 is a protein that in humans is encoded by the BRD9 gene. Enables lysine-acetylated histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of SWI/SNF complex.

Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinating enzyme 44; Ubiquitin thioesterase 44; Ubiquitin-specific-processing protease 44; USP44

BRD9

65980

Q9H8M2

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human BRD9 recombinant protein (Position: K7-K271) .

Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia.

Flow Cytometry

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Immunogen affinity purified.

Liquid

Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) . Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.

1. Filippakopoulos, P., Picaud, S., Mangos, M., Keates, T., Lambert, J.-P., Barsyte-Lovejoy, D., Felletar, I., Volkmer, R., Muller, S., Pawson, T., Gingras, A.-C., Arrowsmith, C. H., Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell 149: 214-231, 2012. 2. Flynn, E. M., Huang, O. W., Poy, F., Oppikofer, M., Bellon, S. F., Tang, Y., Cochran, A. G. A subset of human bromodomains recognizes butyryllysine and crotonyllysine histone peptide modifications. Structure 23: 1801-1814, 2015. 3. Gross, M. B. Personal Communication. Baltimore, Md. 6/10/2019.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

82457 MW

6

Ubiquitin specific peptidase 44

Nucleus.

Disintegrin and metalloproteinase domain-containing protein 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.