Anti-BRDT Antibody Picoband® 31.0550 Vervoeging

Bromodomain testis-specific protein is a protein that in humans is encoded by the BRDT gene. BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene.

Transmembrane protein 107; TMEM107; DC20, UNQ638/PRO1268

BRDT

676

Q58F21

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human BRDT recombinant protein (Position: Q795-D947) .

Ubiquitous. .

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity) . .

1. Gaucher, J., Boussouar, F., Montellier, E., Curtet, S., Buchou, T., Bertrand, S., Hery, P., Jounier, S., Depaux, A., Vitte, A.-L., Guardiola, P., Pernet, K., Debernardi, A., Lopez, F., Holota, H., Imbert, J., Wolgemuth, D. J., Gerard, M., Rousseaux, S., Khochbin, S. Bromodomain-dependent stage-specific male genome programming by Brdt. EMBO J. 31: 3809-3820, 2012. 2. Jones, M. H., Numata, M., Shimane, M. Identification and characterization of BRDT: a testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh. Genomics 45: 529-534, 1997. 3. Li, L., Sha, Y., Wang, X., Li, P., Wang, J., Kee, K., Wang, B. Whole-exome sequencing identified a homozygous BRDT mutation in a patient with acephalic spermatozoa. Oncotarget 8: 19914-19922, 2017.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

15503 MW

6

Transmembrane protein 107

Membrane ; Multi-pass membrane protein .

Transmembrane protein 107

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.