Anti-BUB1 Antibody Picoband® 31.0550 Vervoeging

BUB1, also known as mitotic checkpoint serine/threonine kinase, is an enzyme that in humans is encoded by the BUB1 gene. It is mapped to 2q13. BUB1 is first identified in genetic screens of Saccharomyces cerevisiae. The protein is bound to kinetochores and plays a key role in the establishment of the mitotic spindle checkpoint and chromosome congression. The mitotic checkpoint kinase is evolutionary conserved in organisms as diverse as Saccharomyces cerevisiae and humans. Loss-of-function mutations or absence of BUB1 has been reported to result in aneuploidy, chromosomal instability (CIN) and premature senescence. The protein kinase BUB1 possesses versatile and distinct functions during the cell cycle, mainly in the SAC and chromosome alignment during metaphase.

RNA-binding protein FUS; 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein; FUS; TLS

BUB1

699

O43683

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human BUB1 recombinant protein (Position: E26-K1085) .

Ubiquitous.

Flow Cytometry

Cancer, Cancer Susceptibility, Epigenetics and Nuclear Signaling, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Signal Transduction, Transcription, Transcription Factors

Immunogen affinity purified.

Liquid

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.

1. Entrez Gene: BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 2. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (March 1998) . Mutations of mitotic checkpoint genes in human cancers. Nature 392 (6673) : 300–3. 3. Roberts BT, Farr KA, Hoyt MA (December 1994) . The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol. Cell. Biol. 14 (12) : 8282–91.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

FUS RNA binding protein

Nucleus

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.