Anti-c-Abl (C-terminaal gebied) Antilichaam

The c-Abl proto-oncogene encodes a nonreceptor type protein tyrosine kinase that is widely expressed and is distributed in both the nucleus and the cytoplasm of cells. It has been implicated in regulation of cell proliferation, differentiation, apoptosis, cell adhesion, and stress response. A variety of stimuli activate c-Abl kinase including integrin activation, PDGF stimulation, and binding to proteins, such as c-Jun. Tyrosine phosphorylation is important for the regulation of c-Abl kinase activity. Tyrosine 245 is located in the linker region between the SH2 and catalytic domains. Phosphorylation of Tyr-245 is involved in activation of c-Abl kinase activity. Tyrosine 412 is located in the kinase activation loop of c-Abl, and phosphorylation of this residue is required for kinase activity. Thus, phosphorylation of Tyr-245 and Tyr-412 may be critical for activation of c-Abl in a variety of cell signaling pathways.

Our c-Abl (C-terminal region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat c-Abl (C-terminal region) and is protein g purified. It is great for use in ELISA, WB.

Our c-Abl (C-terminal region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat c-Abl (C-terminal region) and is Protein G purified. It is great for use in WB.

BCR-Abl, p150, Abelson murine leukemia viral oncogene homolog 1

ABL1

P00519

Human, Mouse, and Rat

Clone (M209) was generated from a recombinant protein corresponding to the C-terminal region of human c-Abl.

C-Abl (C-terminal region)

M209

Unconjugated

ELISA, WB

Apoptosis, Cell Adhesion Molecules, Cell Signaling, Cytoskeletal Regulation, Kinase Signaling, DNA Damage and Repair, Oncoproteins

Protein G Purified

PBS + 0.2% gelatin and 0.09% NaN3.

145

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Protein G purified culture supernatant.

1:1000

This antibody detects a 145 kDa* protein corresponding to c-Abl on SDS-PAGE immunoblots of human K-562 and HL-60 cells, and mouse ANN-1 cells.

Western blots performed on each lot.

Mouse

Liquid

IgG1

Human

Quality Control: WB

AB_2289011