Anti-C-C chemokine receptor type 4 CCR4 Antibody Picoband® fluoroc647 Vervoeging

CCR4, C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194) . The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines. The CCR4 gene is mapped to chromosome 3. Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; CD194; Ccr4; Cmkbr4

CCR4

12773

P51680

Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of mouse CCR4, identical to the related rat sequence.

Expressed in the thymus, macrophages and T- and B-cells.

Flow Cytometry

Atherosclerosis, Cardiovascular, Chemokines, Immunology, Innate Immunity, Vascular Inflammation

Immunogen affinity purified.

Liquid

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G (i) proteins which activate a phosphatidylinositol- calcium second messenger system. Could play a role in lipopolysaccharide (LPS) -induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival. .

1. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S., Yoshie, O.The T cell-ed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.J. Biol. Chem. 272: 15036-15042, 1997. 2. Imai, T., Chantry, D., Raport, C. J., Woods, C. L., Nishimura, M., Godiska, R., Yoshie, O., Gray, P. W.Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.J. Biol. Chem. 273: 1764-1768, 1998. 3. Oo, Y. H., Weston, C. J., Lalor, P. F., Curbishley, S. M., Withers, D. R., Reynolds, G. M., Shetty, S., Harki, J., Shaw, J. C., Eksteen, B., Hubscher, S. G., Walker, L. S. K., Adams, D. H.Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.J. Immun. 184: 2886-2898, 2010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

41408 MW

No cross reactivity with other proteins.

6

C-C chemokine receptor type 4

Cell membrane; Multi-pass membrane protein.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

C-C chemokine receptor type 4 (C-C CKR-4/CC-CKR-4/CCR-4/CCR4)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.