Anti-c-Fos Antibody Picoband® 0,00647 Vervoeging

The human oncogene c-fos is cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. c-Fos is encoded by the FOS gene. FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor, Fos, in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.

Proto-oncogene c-Fos; Cellular oncogene fos; G0/G1 switch regulatory protein 7; FOS; G0S7

FOS

2353

P01100

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human c-Fos, identical to the related rat and mouse sequences.

Flow Cytometry

Cancer, Cancer Susceptibility, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Transcription, Transcription Factors

Immunogen affinity purified.

Liquid

Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. .

1. Barker, P. E.; Rabin, M.; Watson, M.; Breg, W. R.; Ruddle, F. H.; Verma, I. M. : Human c-fos oncogene mapped within chromosomal region 14q21-q31. Proc. Nat. Acad. Sci. 81: 5826-5830, 1984. 2. Saez, E.; Rutberg, S. E.; Mueller, E.; Oppenheim, H.; Smoluk, J.; Yuspa, S. H.; Spiegelman, B. M. : c-fos is required for malignant progression of skin tumors. Cell 82: 721-732, 1995. 3. Grigoriadis, A. E.; Wang, Z.-Q.; Wagner, E. F. : Fos and bone cell development: lessons from a nuclear oncogene. Trends Genet. 11: :436-441, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

40695 MW

No cross reactivity with other proteins.

6

Proto-oncogene c-Fos

Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.

Belongs to the bZIP family. Fos subfamily.

Proto-oncogene c-Fos

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.