Anti-c-Maf Konijn Monoklonale Antilichaam

Boster Bio Anti-c-Maf Rabbit Monoclonal Antibody catalog # M00654. Tested in IHC application. This antibody reacts with Human, Mouse, Rat.

Transcription factor Maf; Proto-oncogene c-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog; MAF

MAF

4094

O75444

Human, Mouse, Rat

A synthesized peptide derived from human c-Maf

Clone: DHI-13

Expressed in endothelial cells. .

IHC

Apoptosis, Cancer, Cell Biology, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Immune System Diseases, Immunology, Oncoproteins, Oncoproteins/Suppressors, Transcription, Transcription Factors

Affinity-chromatography

0.5mg/ml

Liquid

Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity) . When overexpressed, represses anti-oxidant response element (ARE) - mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00654

38492 MW

42 kDa

Transcription factor Maf

Nucleus .

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.