Anti-c-Myc Monoklonale Antilichaam (Kloon: 9E10)

C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2) -induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.

Myc proto-oncogene protein; Proto-oncogene c-Myc; Transcription factor p64; Myc

MYC

4609

P01106

Human

Synthetic peptide corresponding to residues 408-439 of the human p62c-Myc protein.

Myc proto-oncogene protein

9E10

WB, IHC-P, ICC

Ascites

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/mL.

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Western blot : 4μg/ml; Immunohistochemistry (Paraffin-embedded Section) : 8μg/ml; Immunocytochemistry : 1μg/ml

Mouse IgG1