Anti-C-terminaal-bindend eiwit 2 CTBP2 Antibody Picoband® 0,00647 Vervoeging

The E1a region of group C adenoviruses encodes 2 nearly identical proteins that are largely responsible for the oncogenic properties of adenoviruses. The CTBP1 protein binds to the C-terminal half of these E1A proteins. It's predicted that CTBP2 is a 445-amino acid protein and it is 72% identical to CTBP1. The CTBP2 gene is mapped to chromosome 10q26.13. CTBP2 is a mammalian corepressor that targets diverse transcriptional regulators. It bounds the short medial portion of delta-EF1 containing the PLDLSL motif and it enhances transrepression activity of delta-EF1.

C-terminal-binding protein 2; CtBP2; CTBP2

CTBP2

1488

P56545

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human CTBP2, identical to the related rat and mouse sequences.

Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.

Flow Cytometry

Cell Type Marker, Co-Factors, Epigenetics and Nuclear Signaling, Microbiology, Neuron Marker, Neuroscience, Synapse Marker, Transcription

Immunogen affinity purified.

Liquid

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity) . .

1. Thomas, G., Jacobs, K. B., Yeager, M., Kraft, P., Wacholder, S., Orr, N., Yu, K., Chatterjee, N., Welch, R., Hutchinson, A., Crenshaw, A., Cancel-Tassin, G., and 27 others.Multiple loci identified in a genome-wide association study of prostate cancer.Nature Genet. 40: 310-315, 2008. 2. Turner, J., Crossley, M.Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators.EMBO J. 17: 5129-5140, 1998. 3. Furusawa, T., Moribe, H., Kondoh, H., Higashi, Y.Identification of CtBP1 and CTBP2 as corepressors of zinc finger-homeodomain factor delta-EF1.Molec. Cell. Biol. 19: 8581-8590, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

48945 MW

No cross reactivity with other proteins.

6

C-terminal-binding protein 2

Nucleus . Cell junction, synapse .

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.

C-terminal-binding protein 2 (CtBP2)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.