Anti-C19orf10/MYDGF Antilichaam Picoband® 31.0647 Vervoeging

Human SF20 (Stromal cell-derived growth factor SF20, C19orf10, MYDGF1, Myeloid-derived growth factor1 also formerly known as IL25) is a 15 kDa (predicted) bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction. SF20 stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1 mediated signaling pathway. It is thought to inhibit cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway and is involved in endothelial cell proliferation and angiogenesis.

Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein; GJC1; GJA7

MYDGF

56005

Q969H8

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human C19orf10/MYDGF recombinant protein (Position: V32-L173) .

Ubiquitously expressed.

Flow Cytometry

Cell Adhesion, Cytoskeleton/ECM, Signal Transduction

Immunogen affinity purified.

Liquid

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

1. Tulin, E. E., Onoda, N., Nakata, Y., Maeda, M., Hasegawa, M., Nomura, H., Kitamura, T. SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation. J. Immun. 167: 6338-6347, 2001. Note: Retraction: J. Immun. 170: 1593 only, 2003. 2. Wang, P., Mariman, E., Keijer, J., Bouwman, F., Noben, J.-P., Robben, J., Renes, J. Profiling of the secreted proteins during 3T3-L1 adipocyte differentiation leads to the identification of novel adipokines. Cell. Molec. Life Sci. 61: 2405-2417, 2004. 3. Weiler, T., Du, Q., Krokhin, O., Ens, W., Standing, K., El-Gabalawy, H., Wilkins, J. A. The identification and characterization of a novel protein, c19orf10, in the synovium. Arthritis Res. Ther. 9: R30, 2007. Note: Electronic Article.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

45470 MW

6

Gap junction gamma-1 protein

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Gap junction gamma-1 protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.