Anti-C19orf2/URI1 Antibody Picoband® fluoro488 Vervoeging

Unconventional prefoldin RPB5 interactor, also called URI1, is a protein that in humans is encoded by the URI1 gene. This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22.

Zinc finger protein Helios; Ikaros family zinc finger protein 2; IKZF2; HELIOS, ZNFN1A2

URI1

8725

O94763

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human C19orf2/URI1 recombinant protein (Position: K89-Q532) .

Ubiquitous. High expression in liver, spleen, pancreas and kidney.

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Associates with Ikaros at centromeric heterochromatin.

1. Chaves-Perez, A., Yilmaz, M., Perna, C., de la Rosa, S., Djouder, N. URI is required to maintain intestinal architecture during ionizing radiation. Science 364: eaaq1165, 2019. Note: Electronic Article. 2. Dorjsuren, D., Lin, Y., Wei, W., Yamashita, T., Nomura, T., Hayashi, N., Murakami, S. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. Molec. Cell Biol. 18: 7546-7555, 1998. 3. Gstaiger, M., Luke, B., Hess, D., Oakeley, E. J., Wirbelauer, C., Blondel, M., Vigneron, M., Peter, M., Krek, W. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science 302: 1208-1212, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39411 MW

6

IKAROS family zinc finger 2

Nucleus.

Zinc finger protein Helios

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.