Anti-C20orf74/RALGAPA2 Antilichaam Picoband®

Predicted to enable GTPase activator activity and protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. Located in cytosol and plasma membrane.

Boster Bio Anti-C20orf74/RALGAPA2 Antibody Picoband® catalog # A10416-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

E3 ubiquitin-protein ligase RNF169; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169; RNF169; KIAA1991

RALGAPA2

57186

Q2PPJ7

Human

No cross-reactivity with other proteins.

E.coli-derived human C20orf74/RALGAPA2 recombinant protein (Position: R246-Q1556) .

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

WB, Flow Cytometry, ELISA

Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.

1. Gridley, S., Chavez, J. A., Lane, W. S., Lienhard, G. E. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. Cell. Signal. 18: 1626-1632, 2006. 2. Gross, M. B. Personal Communication. Baltimore, Md. 4/6/2020. 3. Saito, R., Shirakawa, R., Nishiyama, H., Kobayashi, T., Kawato, M., Kanno, T., Nishizawa, K., Matsui, Y., Ohbayashi, T., Horiguchi, M., Nakamura, T., Ikeda, T., Yamane, K., Nakayama, E., Nakamura, E., Toda, Y., Kimura, T., Kita, T., Ogawa, O., Horiuchi, H. Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene 32: 894-902, 2013.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A10416-1

41409 MW

250 kDa

6

Ring finger protein 169

Nucleoplasm.

Protein NDRG3

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.