Anti-C7orf47/PPP1R35 Antibody Picoband®

PPP1R35 is a putative regulator of protein phosphatase-1. PPP1R35 is a centrosomal protein that regulates centriole elongation and centriole-to-centrosome conversion. Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity.

Boster Bio Anti-C7orf47/PPP1R35 Antibody Picoband® catalog # A15208-1. Tested in ELISA, IF, ICC, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Transmembrane protein 240; TMEM240; C1orf70

PPP1R35

221908

Q8TAP8

Human

No cross-reactivity with other proteins.

E.coli-derived human C7orf47/PPP1R35 recombinant protein (Position: E27-A253) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

WB, ICC, IF, Flow Cytometry, ELISA

Cell Biology

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Fong, C. S., Ozaki, K., Tsou, M.-F. B. PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion. Molec. Biol. Cell 29: 2801-2808, 2018. 2. Gross, M. B. Personal Communication. Baltimore, Md. 7/1/2020. 3. Hendrickx, A., Beullens, M., Ceulemans, H., Abt, T. D., Van Eynde, A., Nicolaescu, E., Lesage, B., Bollen, M. Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem. Biol. 16: 365-371, 2009.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A15208-1

19908 MW

30 kDa

6

Transmembrane protein 240

Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .

Transmembrane protein 240

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.