Anti-Caldesmon (Smooth) Cald1 Antilichaam (Monoclonal, hHCD)

Caldesmon is a potential actomyosin regulatory protein found in smooth muscle and nonmuscle cells. The predicted smooth-muscle polypeptide is 793 amino acids long. The high molecular weight caldesmon (h-CaD) is predominantly expressed in smooth muscles, whereas the low molecular weight caldesmon (l-CaD) is widely distributed in nonmuscle tissues and cells. Hayashi et al. (1992) demonstrated that the human CDM gene is composed of 14 exons.

Boster Bio Anti-Caldesmon (Smooth) Cald1 Antibody (Monoclonal, hHCD) catalog # MA1009. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rabbit.

Non-muscle caldesmon; CDM; L-caldesmon; Cald1

CALD1

Human (800), Mouse (109624), Rat (25687)

Q62736

Human, Mouse, Rabbit

No cross-reactivity with other proteins

Human uterus smooth muscle extract.

Clone: hHCD

High-molecular-weight caldesmon (h-caldesmon) is predominantly expressed in smooth muscles, whereas low- molecular-weight caldesmon (l-caldesmon) is widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.

IHC, WB

Actin Binding Proteins, Actin, etc., Cardiovascular, Contractility, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Ascites

Add 1ml of PBS buffer will yield a concentration of 100 ug/ml

Lyophilized

Add 1ml of PBS buffer will yield a concentration of 100 ug/ml

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments) . Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration. .

1. Humphrey, M. B.; Herrera-Sosa, H.; Gonzalez, G.; Lee, R.; Bryan, J. : Cloning of cDNAs encoding human caldesmons. Gene 112: 197-204, 1992. 2. Hayashi, K.; Yano, H.; Hashida, T.; Takeuchi, R.; Takeda, O.; Asada, K.; Takahashi, E.; Kato, I.; Sobue, K. : Genomic structure of the human caldesmon gene. Proc. Nat. Acad. Sci. 89: 12122-12126, 1992.

At -20°C for one year and at 4°C for one month from date of receipt. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=MA1009

60584 MW

61 kDa

No cross reactivity with other proteins.

Non-muscle caldesmon

Cytoplasm, cytoskeleton . Cytoplasm, myofibril . On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle) . .

Belongs to the calcineurin regulatory subunit family.

Caldesmon

Mouse IgG1

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.