Anti-Calponine/CNN1 Antibody Picoband® fluoro488 Vervoeging

Calponin is a basic 34-kD protein first isolated from chicken gizzard and bovine aorta. This gene is mapped to 19p13.2. It is specifically expressed in smooth muscle and binds calmodulin, actin, and tropomyosin. It is able to inhibit the ATPase activity of myosin and is though to play a role in smooth muscle contraction. Calponin is a smooth muscle specific, actin-, tropomyosin- and calmodulin-binding protein though to be involved in some way in the regulation or modulation of contraction.

Calponin-1; Basic calponin; Calponin H1, smooth muscle; CNN1

CNN1

1264

P51911

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Calponin, different from the related mouse and rat sequences by two amino acids.

Smooth muscle, and tissues containing significant amounts of smooth muscle.

Flow Cytometry

Actin Binding Proteins, Actin, etc., Cardiovascular, Cytoskeleton, Cytoskeleton/ECM, Mesenchymal Stem Cells, Microfilaments, Signal Transduction, Stem Cells, Vasculature

Immunogen affinity purified.

Liquid

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity) . .

1. Miano, J. M., Krahe, R., Garcia, E., Elliott, J. M., Olson, E. N. Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene. Gene 197: 215-224, 1997. 2. Miano, J. M., Thomas, S., Disteche, C. M. Expression and chromosomal mapping of the mouse smooth muscle calponin gene. Mammalian Genome 12: 187-191, 2001. 3. Strasser, P., Gimona, M., Moessler, H., Herzog, M., Small, J. V. Mammalian calponin: identification and expression of genetic variants. FEBS Lett. 330: 13-18, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

33170 MW

No cross reactivity with other proteins.

6

Calponin-1

Nucleus . Cytoplasm . Accumulates in aggresomes under proteasome inhibition conditions.

Belongs to the calponin family.

Calponin-1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.