Anti-CaMK/CAMKK1 Antibody Picoband® fluoro488 Vervoeging

CAMKK1, Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The CAMKK1 gene is mapped to chromosome 17. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca (2+) /calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.Camkk1binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca (2+) -independent activity. Camkk1 catalyzed a 10-fold increase in the total activity of Camk1 and had no effect on Camk2. Cotransfection of COS-7 cells with Camkk1 and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, suggesting that Camkk1 enhances Camk4-mediated transcriptional regulation.

Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1;2.7.11.17; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha; Camkk1; Camkk

CAMKK1

55984

Q8VBY2

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of mouse CaMKK, different from the related human sequence by three amino acids, and from the related rat sequence by two amino acids.

Widely expressed. Differentially expressed in various brain regions. .

Flow Cytometry

Calcium Signaling, Calmodulin Pathway, Neuroscience, Neurotransmission, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. .

1. Blaeser, F., Sanders, M. J., Truong, N., Ko, S., Wu, L. J., Wozniak, D. F., Fanselow, M. S., Zhuo, M., Chatila, T. A.Long-term memory deficits in pavlovian fear conditioning in Ca (2+) /calmodulin kinase kinase alpha-deficient mice.Molec. Cell. Biol. 26: 9105-9115, 2006. 2. Tokumitsu, H., Enslen, H., Soderling, T. R.Characterization of a Ca (2+) /calmodulin-dependent protein kinase cascade: molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase.J. Biol. Chem. 270: 19320-19324, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

55838 MW

No cross reactivity with other proteins.

6

Calcium/calmodulin-dependent protein kinase kinase 1

Cytoplasm . Nucleus .

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1/CaM-kinase kinase 1/CaMKK 1)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.