Anti-CAPN5 Antibody Picoband® 31.0550 Vervoeging

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene. Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.

CAPN5

726

O15484

Human, Mouse, Rat

E.coli-derived human CAPN5 recombinant protein (Position: N583-N616) . Human CAPN5 shares 84.8% and 78.8% amino acid (aa) sequence identity with mouse and rat CAPN5, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Bennett, S. R., Folk, J. C., Kimura, A. E., Russell, S. R., Stone, E. M., Raphtis, E. M. Autosomal dominant neovascular inflammatory vitreoretinopathy. Ophthalmology 97: 1125-1135, 1990. 2. Dear, N., Matena, K., Vingron, M., Boehm, T. A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics 45: 175-184, 1997. 3. Franz, T., Winckler, L., Boehm, T., Dear, T. N. Capn5 is expressed in a subset of T cells and is dispensable for development. Molec. Cell. Biol. 24: 1649-1654, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.