Anti-Carbonic Anhydrase 9/CA9 Antibody Picoband® fluoro594 Vervoeging

Carbonic anhydrase IX (CA9/CA IX) is an enzyme that in humans is encoded by the CA9 gene. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

Myosin-binding protein C, cardiac-type; Cardiac MyBP-C; C-protein, cardiac muscle isoform; MYBPC3

CA9

768

Q16790

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human Carbonic Anhydrase 9/CA9 recombinant protein (Position: D146-D414) .

Red blood cells.

Flow Cytometry

Cardiovascular, Contractility, Hypertrophy

Immunogen affinity purified.

Liquid

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

1. Hewett-Emmett, D., Tashian, R. E. Functional diversity, conservation, and convergence in the evolution of the alpha-, beta- and gamma- carbonic anhydrase gene families. Molec. Phylogenet. Evol. 5: 50-77, 1996. 2. Ivanov, S. V., Kuzmin, I., Wei, M.-H., Pack, S., Geil, L., Johnson, B. E., Stanbridge, E. J., Lerman, M. I. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc. Nat. Acad. Sci. 95: 12596-12601, 1998. 3. Nakagawa, Y., Uemura, H., Hirao, Y., Yoshida, K., Saga, S., Yoshikawa, K. Radiation hybrid mapping of the human MN/CA9 locus to chromosome band 9p12-p13. Genomics 53: 118-119, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Myosin binding protein C, cardiac

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.