Anti-CARD10 Antibody Picoband® 31.0550 Vervoeging

Caspase recruitment domain-containing protein 10 is a protein in the CARD-CC protein family that in humans is encoded by the CARD10 gene. The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B through BCL10.

CARD10; CARMA3; Caspase recruitment domain-containing protein 10; CARD-containing MAGUK protein 3; Carma 3

CARD10

29775

Q9BWT7

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human CARD10 recombinant protein (Position: E63-R1014) . Human CARD10 shares 90.7% amino acid (aa) sequence identity with mouse CARD10.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Gaide, O., Martinon, F., Micheau, O., Bonnet, D., Thome, M., Tschopp, J. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappa-B activation. FEBS Lett. 496: 121-127, 2001. 2. Grabiner, B. C., Blonska, M., Lin, P.-C., You, Y., Wang, D., Sun, J., Darnay, B. G., Dong, C., Lin, X. CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-kappa-B activation. Genes Dev. 21: 984-996, 2007. 3. McAllister-Lucas, L. M., Inohara, N., Lucas, P. C., Ruland, J., Benito, A., Li, Q., Chen, S., Chen, F. F., Yamaoka, S., Verma, I. M., Mak, T. W., Nunez, G. Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappa-B induction. J. Biol. Chem. 276: 30589-30597, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

116 kDa

6

Caspase recruitment domain family member 10

Caspase recruitment domain-containing protein 10

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.